Molecular modelling and bioinformatics

Modesto Orozco

Group Leader
Professor (Biochemistry and Molecular Biology Dept. - UB)

Office Tel : +34 93 403 71 56
Lab Tel : +34 93 403 71 55
e-mail : modesto.orozcoirbbarcelona.org

Research Interests

Our research focuses on the study of molecular recognition processes of biological significance from methodological and application points of view. The main subjects addressed are the structure of non-standard nucleic acids, the dynamic properties of macromolecules, and protein-ligand and protein-protein recognition.

Research Lines

Methodological aspects

• Analysis of the effect of solvent in molecular recognition. Continuum methods are compared to analyse explicit solvent simulations.
• Fine-tuning of the parametrization of molecular dynamics simulations.

Studies on Small Models

• Theoretical studies of small model systems of large biological impact. This includes, among others, tautomeric and isomerism processes, stacking interactions, salt bridges, hydrogen bonding, cation-π interactions, and general mechanisms of molecular recognition.

Studies on Proteins

• We study the basis of protein interactions, including those of pharmacological importance. In addition, we develop methods to examine both protein-protein and protein-ligand recognition.
• We analyse protein flexibility using massive molecular dynamics simulations.

Studies on Nucleic Acids

• We use molecular dynamics and statistical mechanics to examine anomalous forms of nucleic acids. Particular attention is paid to the study of conformational transitions in DNA, drug-DNA interactions, and the analysis of triple helices and other structures of potential impact in antigene or antisense therapies.

Bioinformatics

• Data mining of genomic DNA to identify regions with unusual structures or unusual mechanical properties.
• Development of algorithms for the prediction of the pathological character of single nucleotide polymorphisms.
• Structural study of alternative splicing in proteins.

Funding

This group receives financial support from the following sources:

• Fundación Ramón Areces (Ramón Areces Foundation)
  
• Ministerio de Educación y Ciencia (MEC - Spanish Ministry of Science and Education)
• Fundación BBVA (BBVA Foundation)
  
• CIRIT – Generalitat de Catalunya (Interdepartmental Committee for Technological Research and Innovation)(Government of Catalonia)
  

More info

• Orozco Group Scientific Report 2008
• Orozco Group Scientific Report 2007
• Orozco Group Scientific Report 2005-2006
• Molecular Modelling Website

Molecular modelling and bioinformatics

An atomistic view to the gas phase proteome
Meyer T, de la Cruz X and Orozco M
Structure (2009)

On the performance of continuum solvation methods. A comment on Universal Approaches to Solvation Modeling
Klamtz A, Mennucci B, Tomasi J, Barone V, Curutchet C, Orozco M, Luque FJ
Acc Chem Res (2009)

Comparison of molecular dynamics and superfamily spaces of protein domain deformation
Velázquez-Muriel JA, Rueda M, Isabel C, Pascual-Montano A, Orozco M and Carazo JM
BMC Struct Biol, 9 (1), 6 (2009)

X-pol potential: An electronic structure-based force field for molecular dynamics simulation of a solvated protein in water
Xie W, Orozco M, Truhlar D and Gao J
J Chem Theor Comput, 5 (3), 459-467 (2009)

Conformationally rigid nucleoside probes help understand the role of sugar pucker and nucleobase orientation in the thrombin-binding aptamer
Saneyoshi H, Mazzini S, Aviñó A, Portella G, González C, Orozco M, Marquez VE and Eritja R
Nucleic Acids Res, 37 (17), 5589-5601 (2009)

Unique tautomeric and recognition properties of thioketothymines?
Faustino I, Aviño A, Marchán I, Luque FJ, Eritja R and Orozco M
J Am Chem Soc, 131 (35), 12845-12853 (2009)

The use of conformationally rigid nucleoside probes to study the role of sugar pucker and nucleobase orientation in the thrombin binding aptamer
Saneyoshi H, Mazzini S, Aviñó A, Portella G, González C, Orozco M, Marquez VE and Eritja R
Nucleic Acids Symp Ser, 53, 109-110 (2009)

COCO: A simple tool to enrich the representation of conformational variability in NMR structures
Laughton CA, Orozco M and Vranken W
Proteins, 75 (1), 206-216 (2008)

Exploring the suitability of coarse-grained techniques for the representation of protein dynamics
Emperador A, Carrillo O, Rueda M and Orozco M
Biophys J, 95 (5), 2127-2138 (2008)

Interoperability with Moby 1.0--it's better than sharing your toothbrush!
The Biomoby consortium (including Orozco M, Gelpí JL and others)
Brief Bioinform, 9 (3), 220-231 (2008)

Extension of the MST continuum solvation model to the RM1 semiempirical Hamiltonian
Forti F, Barril X, Luque FJ and Orozco M
J Comput Chem, 29 (4), 578-587 (2008)

Theoretical analysis of antisense duplexes: determinants of the RNase H susceptibility
Noy A, Luque FJ and Orozco M
J Am Chem Soc, 130 (11), 3486-3496 (2008)

8-Amino guanine accelerates tetramolecular G-quadruplex formation
Gros J, Aviñó A, Lopez de la Osa J, González C, Lacroix L, Pérez A, Orozco M, Eritja R and Mergny JL
Chem Commun, 7 (25), 2926-2928 (2008)

GRID-MD-A tool for massive simulation of protein channels
Carrillo O and Orozco M
Proteins, 70 (3), 892-899 (2008)

Ab initio study of naphtho-homologated DNA bases
Vázquez-Mayogoita A, Huertas O, Fuentes-Cabrera M, Sumpter BG, Orozco M and Luque FJ
J Phys Chem B, 112 (7), 2179-2186 (2008)

Recent advances in the study of nucleic acid flexibility by molecular dynamics
Orozco M, Noy A and Pérez A
Curr Opin Struct Biol, 18 (2), 185-193 (2008)

DNAlive: a tool for the physical analysis of DNA at the genomic scale
Goñi JR, Fenollosa C, Pérez A, Torrents D and Orozco M
Bioinformatics, 24 (15), 1731-1732 (2008)

Geometrical and electronic structure variability of the sugar-phosphate backbone in nucleic acids
Svozil D, Sponer JE, Marchan I, Pérez A, Cheatham TE 3rd, Forti F, Luque FJ, Orozco M and Sponer J
J Phys Chem B, 112 (27), 8188-8197 (2008)

Induction effects in metal cation-benzene complexes
Soteras I, Orozco M and Luque FJ
Phys Chem Chem Phys, 10 (19), 2616-2624 (2008)

Structure-directed reversion in the pi-facial stereoselective alkylation of chiral bicyclic lactams
Soteras I, Lozano O, Escolano C, Orozco M, Amat M, Bosch J and Luque FJ
J Org Chem, 73 (19), 7756-7763 (2008)

Target flexibility: an emerging consideration in drug discovery and design
Cozzini P, Kellogg GE, Spyrakis F, Abraham DJ, Costantino G, Emerson A, Fanelli F, Gohlke H, Kuhn LA, Morris GM, Orozco M, Pertinhez TA, Rizzi M and Sotriffer CA
J Med Chem, 51 (20), 6237-6255 (2008)

Towards a molecular dynamics consensus view of B-DNA flexibility
Pérez A, Lankas F, Luque FJ and Orozco M
Nucleic Acids Res, 36 (7), 2379-2394 (2008)

United-atom discrete molecular dynamics of proteins using physics-based potentials
Emperador A, Meyer T and Orozco M
J Chem Theory Comput, 4 (12), 2001-2010 (2008)

Solvation enthalpies of neutral solutes in water and octanol
Bidon-Chanal A, Huertas O, Orozco M and Luque FJ
Theor Chem Acc, 123 (1-2), 11-20 (2008)

Derivation of distributed models of atomic polarizability for molecular simulations
Soteras I, Curutchet C, Bidon-Chanal A, Dehez F, Angyan J, Orozco M, Chipot C and Luque FJ
J Chem Theory Comput, 3 (6), 1901-1913 (2007)

The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane
Fort J, de la Ballina LR, Burghardt HE, Ferrer-Costa C, Turnay J, Ferrer-Orta C, Usón I, Zorzano A, Fernández-Recio J, Orozco M, Lizarbe MA, Fita I and Palacín M
J Biol Chem, 282 (43), 31444-31452 (2007)

Binding affinities of oligonucleotides and PNAs containing phenoxazine and G-clamp cytosine analogues are unusually sequence-dependent
Ortega JA, Blas JR, Orozco M, Grandas A, Pedroso E and Robles J
Org Lett, 9 (22), 4503-4506 (2007)

Dynamics of B-DNA on the microsecond time scale
Pérez A, Luque FJ and Orozco M
J Am Chem Soc, 129 (47), 14739-14745 (2007)

Theoretical study of large conformational transitions in DNA: the B<-->A conformational change in water and ethanol/water
Noy A, Pérez A, Laughton CA and Orozco M
Nucleic Acids Res, 35 (10), 3330-3338 (2007)

Thorough validation of protein normal mode analysis: a comparative study with essential dynamics
Rueda M, Chacón P and Orozco M
Structure, 15 (5), 565-575 (2007)

The (in)dependence of alternative splicing and gene duplication
Talavera D, Vogel C, Orozco M, Teichmann SA and de la Cruz X
PLoS Comput Biol, 3 (3), 375-388 (2007)

Refinement of the AMBER force field for nucleic acids: improving the description of alpha/gamma conformers
Pérez A, Marchán I, Svozil D, Sponer J, Cheatham TE 3rd, Laughton CA and Orozco M
Biophys J, 92 (11), 3817-3829 (2007)

A procedure for identifying homologous alternative splicing events
Talavera D, Hospital A, Orozco M and de la Cruz X
BMC Bioinformatics, 8, 260-271 (2007)

A consensus view of protein dynamics
Rueda M, Ferrer-Costa C, Meyer T, Pérez A, Camps J, Hospital A, Gelpí JL and Orozco M
Proc Natl Acad Sci USA, 104 (3), 796-801 (2007)

Exploring the dynamics of calix[4]pyrrole: effect of solvent and fluorine substitution
Blas JR, López-Bes JM, Márquez M, Sessler JL, Luque FJ and Orozco M
Chemistry, 13 (4), 1108-1116 (2007)

Characterization of compensated mutations in terms of structural and physico-chemical properties
Ferrer-Costa C, Orozco M and de la Cruz X
J Mol Biol, 365 (1), 249-256 (2007)

Dissection of the recognition properties of p38 MAP kinase. Determination of the binding mode of a new pyridinyl-heterocycle inhibitor family
Soliva R, Gelpi JL, Almansa C, Virgili M and Orozco M
J Med Chem, 50 (2), 283-293 (2007)

A hydrophobic similarity analysis of solvation effects on nucleic acid bases
Muñoz-Muriedas J, Barril X, López JM, Orozco M and Luque FJ
J Mol Model, 13 (2), 357-365 (2007)

Triplex formation using oligonucleotide clamps carrying 8-aminopurines
Aviñó A, Grimau MG, Alvira M, Eritja R, Gargallo R, Orozco M and González C
Nucleosides Nucleotides Nucleic Acids, 26 (8-9), 979-983 (2007)

Continuum analysis of conformational sampling in solution. In Continuum Solvation Models in Chemical Physics: Theory and Application
Orozco M, Marchán I and Soteras I
Mennucci B and Cammi R (Eds), Elsevier, 499-522 (2007)

Determining promoter location based on DNA structure first-principles calculations
Goñi JR, Pérez A, Torrents D and Orozco M
Genome Biol, 8 (12), R263 (2007)

A fast method for the determination of fractional contributions to solvation in proteins
Talavera D, Morreale A, Meyer T, Hospital A, Ferrer-Costa C, Gelpi JL, de la Cruz X, Soliva R, Luque FJ and Orozco M
Protein Sci, 15 (11), 2525-2533 (2006)

Local aromaticity in natural nucleobases and their size-expanded benzo-fused derivatives
Huertas O, Poater J, Fuentes-Cabrera M, Orozco M, Solà M and Luque FJ
J Phys Chem A, 110 (44), 12249-12258 (2006)

Dispersion and repulsion contributions to the solvation free energy: comparison of quantum mechanical and classical approaches in the polarizable continuum model
Curutchet C, Orozco M, Luque FJ, Mennucci B and Tomasi J
J Comput Chem, 27 (15), 1769-1780 (2006)

On the origin of the stereoselectivity in the alkylation of oxazolopiperidone enolates
Soteras I, Lozano O, Gómez-Esqué A, Escolano C, Orozco M, Amat M, Bosch J and Luque FJ
J Am Chem Soc, 128 (20), 6581-6588 (2006)

G-quadruplexes can maintain their structure in the gas phase
Rueda M, Luque FJ and Orozco M
J Am Chem Soc, 128 (11), 3608-3619 (2006)

Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions
Goñi JR, Vaquerizas JM, Dopazo J and Orozco M
BMC Genomics, 7, 63-72 (2006)

Nature of base stacking: reference quantum-chemical stacking energies in ten unique B-DNA base-pair steps
Sponer J, Jurecka P, Marchan I, Luque FJ, Orozco M and Hobza P
Chemistry, 12 (10), 2854-2865 (2006)

Benzoderivatives of nucleic acid bases as modified DNA building blocks
Huertas O, Blas JR, Soteras I, Orozco M and Luque FJ
J Phys Chem A, 110 (2), 510-518 (2006)

Destabilization of quadruplex DNA by 8-aminoguanine
López de la Osa J, González C, Gargallo R, Rueda M, Cubero E, Orozco M, Aviñó A and Eritja R
Chembiochem, 7 (1), 46-48 (2006)

Theoretical study of the Hoogsteen-Watson-Crick junctions in DNA
Cubero E, Luque FJ and Orozco M
Biophys J, 90 (3), 1000-1008 (2006)

Data mining of molecular dynamics trajectories of nucleic acids
Noy A, Meyer T, Rueda M, Ferrer C, Valencia A, Pérez A, de la Cruz X, López-Bes JM, Pouplana R, Fernandez-Recio J, Luque FJ and Orozco M
J Biomol Struct Dyn, 23 (4), 447-456 (2006)

Ligand-induced dynamical regulation of NO conversion in Mycobacterium tuberculosis truncated hemoglobin-N
Bidon-Chanal A, Martí MA, Crespo A, Milani M, Orozco M, Bolognesi M, Luque FJ and Estrin DA
Proteins, 64 (2), 457-464 (2006)

Essential dynamics: a tool for efficient trajectory compression and management
Meyer T, Ferrer-Costa C, Pérez A, Rueda M, Bidon-Chanal A, Luque FJ, Laughton CA and Orozco M
J Chem Theory Comput, 2 (2), 251-258 (2006)

Aromaticity-induced changes in electronic properties of size-expanded DNA bases: Case of xC
Fuentes-Cabrera M, Lipkowski P, Huertas O, Sumpter BG, Orozco M, Luque FJ, Wells JC and Leszczynski J
Int J Quantum Chem, 106 (11), 2339-2346 (2006)

Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease
Muñoz-Ruiz P, Rubio L, García-Palomero E, Dorronsoro I, del Monte-Millán M, Valenzuela R, Usán P, de Austria C, Bartolini M, Andrisano V, Bidon-Chanal A, Orozco M, Luque FJ, Medina M and Martínez A
J Med Chem, 48 (23), 7223-7233 (2005)

MST continuum study of the hydration free energies of monovalent ionic species
Curutchet C, Bidon-Chanal A, Soteras I, Orozco M and Luque FJ
J Phys Chem B, 109 (8), 3565-3574 (2005)

Theoretical study of the truncated hemoglobin HbN: exploring the molecular basis of the NO detoxification mechanism
Crespo A, Martí MA, Kalko SG, Morreale A, Orozco M, Gelpi JL, Luque FJ and Estrin DA
J Am Chem Soc, 127 (12), 4433-4444 (2005)

Hydrophobic molecular similarity from MST fractional contributions to the octanol/water partition coefficient
Muñoz-Muriedas J, Perspicace S, Bech N, Guccione S, Orozco M and Luque FJ
J Comput Aided Mol Des, 19 (6), 401-419 (2005)

PMUT: a web-based tool for the annotation of pathological mutations on proteins
Ferrer-Costa C, Gelpí JL, Zamakola L, Parraga I, de la Cruz X and Orozco M
Bioinformatics, 21 (14), 3176-3178 (2005)

PupasView: a visual tool for selecting suitable SNPs, with putative pathological effect in genes, for genotyping purposes
Conde L, Vaquerizas JM, Ferrer-Costa C, de la Cruz X, Orozco M and Dopazo J
Nucleic Acids Res, 3, 501-505 (2005)

Partition of protein solvation into group contributions from molecular dynamics simulations
Morreale A, de la Cruz X, Meyer T, Gelpí JL, Luque FJ and Orozco M
Proteins, 58 (1), 101-109 (2005)

Use of bioinformatics tools for the annotation of disease-associated mutations in animal models
Ferrer-Costa C, Orozco M and de la Cruz X
Proteins, 61 (4), 878-887 (2005)

Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE
Alonso D, Dorronsoro I, Rubio L, Muñoz P, García-Palomero E, Del Monte M, Bidon-Chanal A, Orozco M, Luque FJ, Castro A, Medina M and Martínez A
Bioorg Med Chem, 13 (24), 6588-6597 (2005)

Nature of minor-groove binders-DNA complexes in the gas phase
Rueda M, Luque FJ and Orozco M
J Am Chem Soc, 127 (33), 11690-11698 (2005)

Are the hydrogen bonds of RNA (AU) stronger than those of DNA (AT)? A quantum mechanics study
Pérez A, Sponer J, Jurecka P, Hobza P, Luque FJ and Orozco M
Chemistry, 11 (17), 5062-5066 (2005)

Extension of the MST model to the IEF formalism: HF and B3LYP parametrizations
Soteras I, Curutchet C, Bidon-Chanal A, Orozco M and Luque FJ
J Mol Struct Theochem, 727 (1-3), 29-40 (2005)

Structure, recognition properties, and flexibility of the DNA.RNA hybrid
Noy A, Pérez A, Márquez M, Luque FJ and Orozco M
J Am Chem Soc, 127 (13), 4910-4920 (2005)

Exploring the essential dynamics of B-DNA
Pérez A, Blas JR, Rueda M, López-Bes JM, de la Cruz X and Orozco M
J Chem Theory Comput, 1, 790-800 (2005)

Exploring the binding mode of semicarbazide-sensitive amine oxidase/VAP-1: identification of novel substrates with insulin-like activity
Marti L, Abella A, De La Cruz X, García-Vicente S, Unzeta M, Carpéné C, Palacín M, Testar X, Orozco M and Zorzano A
J Med Chem, 47 (20), 4865-4874 (2004)

Relative flexibility of DNA and RNA: a molecular dynamics study
Noy A, Pérez A, Lankas F, Javier Luque F and Orozco M
J Mol Biol, 343 (3), 627-638 (2004)

Unconventional interactions between water and heterocyclic nitrogens in protein structures
Stollar EJ, Gelpí JL, Velankar S, Golovin A, Orozco M and Luisi BF
Proteins, 57 (1), 1-8 (2004)

The relative flexibility of B-DNA and A-RNA duplexes: database analysis
Pérez A, Noy A, Lankas F, Luque FJ and Orozco M
Nucleic Acids Res, 32 (20), 6144-6151 (2004)

Theoretical study of the guanine --> 6-thioguanine substitution in duplexes, triplexes, and tetraplexes
Spacková N, Cubero E, Sponer J and Orozco M
J Am Chem Soc, 126 (44), 14642-14650 (2004)

Linear response theory: an alternative to PB and GB methods for the analysis of molecular dynamics trajectories?
Morreale A, de la Cruz X, Meyer T, Gelpí JL, Luque FJ and Orozco M
Proteins, 57 (3), 458-467 (2004)

Effect of bulky lesions on DNA: Solution structure of a DNA duplex containing a cholesterol adduct
Gómez-Pinto I, Cubero E, Kalko SG, Monaco V, van der Marel G, van Boom JH, Orozco M and González C
J Biol Chem, 279 (23), 24552-24560 (2004)

Functional and structural conservation of CBS domains from CLC chloride channels
Estévez R, Pusch M, Ferrer-Costa C, Orozco M and Jentsch TJ
J Physiol, 557 (Pt2), 363-378 (2004)

Alternative splicing mechanisms for the modulation of protein function: conservation between human and other species
Valenzuela A, Talavera D, Orozco M and de la Cruz X
J Mol Biol, 335 (2), 495-502 (2004)

Triplex-forming oligonucleotide target sequences in the human genome
Goñi JR, de la Cruz X and Orozco M
Nucleic Acids Res, 32 (1), 354-360 (2004)

Unique tautomeric properties of isoguanine
Blas JR, Luque FJ and Orozco M
J Am Chem Soc, 126 (1), 154-164 (2004)

Sequence-based prediction of pathological mutations
Ferrer-Costa C, Orozco M and de la Cruz X
Proteins, 57 (4), 811-819 (2004)

Exploring the counterion atmosphere around DNA: what can be learned from molecular dynamics simulations?
Rueda M, Cubero E, Laughton CA and Orozco M
Biophys J, 87 (2), 800-811 (2004)

Antiparallel triple helices. Structural characteristics and stabilization by 8-amino derivatives
Aviñó A, Cubero E, González C, Eritja R and Orozco M
J Am Chem Soc, 125 (51), 13127-16138 (2003)

Molecular modelling and bioinformatics

Modesto Orozco

Group Leader
Professor (Biochemistry and Molecular Biology Dept. - UB)

Office Tel : +34 93 403 71 56
Lab Tel : +34 93 403 71 55
e-mail : modesto.orozcoirbbarcelona.org

Research Associates
Josep Lluís Gelpí
tel +34 93 403 47 07
josep.gelpiirbbarcelona.org

Agustí Emperador
tel +34 93 403 71 55
agusti.emperadorirbbarcelona.org

Manuel Rueda Borrego
manuel.ruedairbbarcelona.org

Postdoctoral Fellows
Oliver Carrillo
tel +34 93 403 71 55
oliver.carrilloirbbarcelona.org

Guillem Portella Carbó
tel +34 93 403 71 55
guillem.portellairbbarcelona.org

Kathryn Collinet
tel +34 93 402 02 28
kathryn.collinetirbbarcelona.org

Nadine Simone Utz
tel +34 93 403 71 55
nadine.utzirbbarcelona.org

Athi Narayanan Naganathan
tel +34 93 403 71 55
athi.naganathanirbbarcelona.org

Santiago Esteban Martin
tel +34 93 403 71 55
santiago.estebanirbbarcelona.org

Federica Battistini
tel +34 93 403 71 55
federica.battistiniirbbarcelona.org

PhD Students
Annalisa Arcella
tel +34 93 403 71 55
annalisa.arcellairbbarcelona.org

Ignacio Faustino Plo
tel +34 93 403 71 55
ignacio.faustinoirbbarcelona.org

Laura Orellana
tel +34 93 403 71 55
laura.orellanairbbarcelona.org

Özgen Deniz
tel +34 93 402 02 28
ozgen.denizirbbarcelona.org

Elisa Durán
tel +34 93 402 02 28
elisa.duranirbbarcelona.org

Oscar Flores
tel +34 93 403 71 55
oscar.floresirbbarcelona.org

Michela Candotti
tel +34 93 403 71 55
michela.candottiirbbarcelona.org

Pedro Sfriso
tel + 34 93 403 71 55
pedro.sfrisoirbbarcelona.org

Research Assistants
José Antonio Alcántara
tel +34 93 403 71 55
jose.alcantarairbbarcelona.org

Chiara Castellazzi
tel +34 93 402 02 28
chiara.castellazziirbbarcelona.org

Adam Hospital Gasch
tel +34 93 403 71 55
adam.hospitalirbbarcelona.org

Carlos Fenollosa Bielsa
tel +34 93 403 71 55
carlos.fenollosairbbarcelona.org

Administrative Assistant
Margarita Pedro
tel +34 93 403 71 55
margarita.pedroirbbarcelona.org

Visiting Scientist
Manuel Marquez
tel + 34 93 403 71 55
manuel.marquezirbbarcelona.org

Molecular modelling and bioinformatics

• 31 May 2010
  Blogs El País
  Four aces and a wild card
  
• 20 May 2010
  Science News
  First ever high resolution observations of DNA unfolding
  

  This is a key process to understand gene activity and DNA replication, and to design drugs to modulate them in the future.

• 7 May 2010
  Institute News
  The Spanish Biophysics Society awards prize to two scientists at IRB Barcelona
  

  Modesto Orozco receives the Bruker Prize and Pau Bernadó the I Prize for Young Investigators.

• 3 March 2009
  Diario Médico
  "MareNostrum", the supercomputer
  
• 1 April 2008
  Revista UB
  Un nou codi en el genoma
  
• 29 January 2008
  El Punt (Girona)
  Científics de Barcelona troben un codi nou en el genoma
  
• 28 January 2008
  Europa Press
  Científicos españoles revelan la existencia de un código en el genoma, clave en la regulación de la expresión génica
  
• 28 January 2008
  Hispanidad
  Científicos españoles revelan la existencia de un código en el genoma, clave en la regulación de la expresión génica
  
• 28 January 2008
  Terra
  Científicos barceloneses descubren un nuevo código en el genoma
  
• 29 January 2008
  Diario Médico
  Hallan un código en el genoma desconocido hasta el momento