Laboratory of Molecular Biophysics
Xavier Salvatella
Investigador Principal
Tel Oficina : +34 93 402 04 59
Tel Lab : +34 93 402 04 61
correo-e : xavier.salvatella
irbbarcelona.org
Introducción
A high resolution description of the structure and dynamics of proteins is a very useful tool to study the properties and the function of these important biomacromolecules and, most importantly, to understand how changes in sequence or environment can lead to disease. The research work carried out at the Laboratory of Molecular Biophysics aims, on the one hand, at developing methods to probe the fluctuations of the structure of proteins by combining experimental data and molecular simulations and, on the other hand, at understanding how changes in such motions relate to the molecular recognition of proteins, to their function and disease.
Laboratory of Molecular Biophysics
Influence of the fluctuations of the alignment tensor on the analysis of the structure and dynamics of proteins using residual dipolar couplings
Salvatella X, Richter B and Vendruscolo M
J Biomol NMR, 40 (1), 71-81 (2008)
Structural analysis of substance P using molecular dynamics and NMR spectroscopy
Corcho FJ, Salvatella X, Canto J, Giralt E and Perez JJ
J Pept Sci, 13 (11), 728-741 (2007)
Protein structure determination from NMR chemical shifts
Cavalli A, Salvatella X, Dobson CM and Vendruscolo M
Proc Natl Acad Sci USA, 104 (23), 9615-9620 (2007)
The MUMO (minimal under-restraining minimal over-restraining) method for the determination of native state ensembles of proteins
Richter B, Gsponer J, Várnai P, Salvatella X and Vendruscolo M
J Biomol NMR, 37 (2), 117-135 (2007)
Determination of the folding transition states of barnase by using PhiI-value-restrained simulations validated by double mutant PhiIJ-values
Salvatella X, Dobson CM, Fersht AR and Vendruscolo M
Proc Natl Acad Sci USA, 102 (35), 12389-12394 (2005)
A new class of foldamers based on cis-gamma-amino-L-proline
Farrera-Sinfreu J, Zaccaro L, Vidal D, Salvatella X, Giralt E, Pons M, Albericio F and Royo M
J Am Chem Soc, 126 (19), 6048-6057 (2004)
Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR
Korzhnev DM, Salvatella X, Vendruscolo M, Di Nardo AA, Davidson AR, Dobson CM and Kay LE
Nature, 430 (6999), 586-590 (2004)
A tetraguanidinium ligand binds to the surface of the tetramerization domain of protein P53
Salvatella X, Martinell M, Gairí M, Mateu MG, Feliz M, Hamilton AD, De Mendoza J and Giralt E
Angew Chem Int Ed Engl, 43 (2), 196-198 (2004)
NMR-based methods and strategies for drug discovery
Salvatella X and Giralt E
Chem Soc Rev, 32 (6), 365-372 (2003)
Laboratory of Molecular Biophysics
Xavier Salvatella
Investigador Principal
Tel Oficina : +34 93 402 04 59
Tel Lab : +34 93 402 04 61
correo-e : xavier.salvatellairbbarcelona.org
Postdoctoral Fellows
Robert Brynmor Fenwick
tel +34 93 402 04 60
robert.fenwickirbbarcelona.org
Maria Francesca Mossuto
tel +34 93 402 04 60
maria.mossutoirbbarcelona.org
