Research Programmes
Cell & Developmental Biology
Cell division laboratory
Cayetano González
Group Leader
ICREA Research Professor
Office Tel : +34 93 403 71 91
Lab Tel : +34 93 403 70 18
e-mail : gonzalez
irbbarcelona.org
Research Interests
We study the mechanisms of cell division through a multidisciplinary approach that combines genetics, and molecular biology and advanced microscopy. As model systems, we use Drosophila and also cultured cells derived from vertebrates.
Research Lines
Protein Traps: Subcellular localisation is a key aspect of protein function.
We have now automated a protein trap protocol (Reviewed in Gonzalez and Bejarano, 2000) which is being applied in several high-content screens.
Spindle assembly in vivo: Direct visualisation is now mandatory to unravel the complex processes that occur within the living cell. Using protocols developed in our laboratory, we are obtaining new data on the behaviour of specific proteins labelled with florescent tags (Rebollo and Gonzalez , 2000; Lange et al., 2002; Sampaio et al., 2001; Rebollo et al., 2004).
Molecular analysis of centrosomes. (Lange et al., 2002; Tavosanis and Gonzalez, 2003). We have recently cloned the gene that encodes a centriolar protein. Our laboratory has access to mutant alleles, functional GFP fusions and antibodies, that will be all instrumental tools in the molecular dissection of this organelle.
Modelling cancer in Drosophila: We are starting to use Drosophila to study some basic principles regarding cell proliferation and malignant growth (Caussinus and González, 2005; Wodarz & Gonzalez, 2006. Previews, Cell).
Funding
This group is financially supported by the following:
- VI Framework Programme Grants, EU
- Ministerio de Educación y Ciencia (Spanish Ministry of Science and Education)
- Generalitat de Catalunya (Government of Catalonia)
More info
Cell division laboratory
Spindle alignment is achieved without rotation after the first cell cycle in Drosophila embryonic neuroblasts
Rebollo E, Roldán M and Gonzalez C
Development, 136 (20), 3393-3397 (2009)
Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling
Martinez AM, Schuettengruber B, Sakr S, Janic A, Gonzalez C and Cavalli G
Nat Genet, 41 (10), 1076-1082 (2009)
Biased segregation of DNA and centrosomes: moving together or drifting apart?
Tajbakhsh S and Gonzalez C
Nat Rev Mol Cell Biol, 10 (11), 804-810 (2009)
Below the convergence
Gonzalez C
Curr Biol, 19 (8), R313-314 (2009)
Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability
Castellanos E, Dominguez P and González C
Curr Biol, 18 (16), 1209-1214 (2008)
Centrosome function during stem cell division: the devil is in the details
Gonzalez C.
Curr Opin Cell Biol, 20 (6), 694-698 (2008)
Drosophila asymmetric division, polarity and cancer
Januschke J and Gonzalez C
Oncogene, 27 (55), 6994-6702 (2008)
Asterless is a centriolar protein required for centrosome function and embryo development in Drosophila
Varmark H, Llamazares S, Rebollo E, Lange B, Reina J, Schwarz H and González C
Curr Biol, 17 (20), 1735-1745 (2007)
Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells
González C
Nat Rev Genet, 8 (6), 462-472 (2007)
Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells
Rebollo E, Sampaio P, Januschke J, Llamazares S, Varmark H and González C
Dev Cell, 12 (3), 467-474 (2007)
Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomes
Dyer N, Rebollo E, Domínguez P, Elkhatib N, Chavrier P, Daviet L, González C and González-Gaitán M
Development, 134 (24), 4437-4447 (2007)
Localized transfection with magnetic beads coated with PCR products and other nucleic acids
Santori MI, Gonzalez C, Serrano L and Isalan M
Nat Protoc, 1 (2), 526-531 (2006)
Connecting cancer to the asymmetric division of stem cells
Wodarz A and Gonzalez C
Cell, 124 (6), 1121-1123 (2006)
Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
Caussinus E and Gonzalez C
Nat Genet, 37 (10), 1125-1129 (2005)
Structure and microtubule-nucleation activity of isolated Drosophila embryo centrosomes characterized by whole mount scanning and transmission electron microscopy
Lange BM, Kirfel G, Gestmann I, Herzog V and González C
Histochem Cell Biol, 124 (3-4), 325-334 (2005)
Localized transfection on arrays of magnetic beads coated with PCR products
Isalan M, Santori MI, Gonzalez C and Serrano L
Nat Methods, 2 (2), 113-118 (2005)
Contribution of noncentrosomal microtubules to spindle assembly in Drosophila spermatocytes
Rebollo E, Llamazares S, Reina J and Gonzalez C
PLoS Biol, 2 (1), 54-64 (2004)
Time-lapse imaging of male meiosis by phase-contrast and fluorescence microscopy
Rebollo E and González C
In “Drosophila Cytogenetics Protocols”, Methods Mol Biol, 247, 77-87 (2004)
gamma-Tubulin function during female germ-cell development and oogenesis in Drosophila
Tavosanis G and Gonzalez C
Proc Natl Acad Sci U SA, 100 (18), 10263-10268 (2003)
Cell division: the place and time of cytokinesis
Gonzalez C
Curr Biol, 13 (9), 363-365 (2003)
Drosophila dd4 mutants reveal that gammaTuRC is required to maintain juxtaposed half spindles in spermatocytes
Barbosa V, Gatt M, Rebollo E, Gonzalez C and Glover DM
J Cell Sci, 116 (Pt 5), 929-941 (2003)
Cell division laboratory
Cayetano González
Group Leader
ICREA Research Professor
Office Tel : +34 93 403 71 91
Lab Tel : +34 93 403 70 18
e-mail : gonzalezirbbarcelona.org
Research Associate
Elena Rebollo Arredondo
tel +34 93 403 70 18
rebolloirbbarcelona.org
Postdoctoral Fellows
Jens Januschke
tel +34 93 403 70 18
januschkeirbbarcelona.org
José Reina Iniesta
tel +34 93 403 70 18
reinairbbarcelona.org
Fabrizio Rossi
tel +34 93 403 70 18
fabrizio.rossiirbbarcelona.org
Zhanna Shcheprova
tel +34 93 403 70 18
zhanna.shcheprovairbbarcelona.org
Bart Lesage
tel +34 93 403 70 18
bart.lesageirbbarcelona.org
PhD Students
Ana Janic
tel +34 93 403 70 18
janicirbbarcelona.org
Eulàlia Scheenaard
tel +34 93 403 70 18
eulalia.scheenaardirbbarcelona.org
Research Assistants
Salud Llamazares
tel +34 93 403 70 18
llamazaresirbbarcelona.org
Jan Peter Heinen
tel +34 903 403 70 18
peter.heinenirbbarcelona.org
Administrative Assistant
Sandra Ricol
tel +34 93 403 99 82
sandra.ricolirbbarcelona.org
Cell division laboratory
- 23 June 2010
Institute News
Five young scientists at IRB Barcelona to attend the Nobel Laureate Meeting in Lindau, GermanyFrom 27 June to 2 July, five young scientists of the Institute for Research in Biomedicine (IRB Barcelona) are to attend the 60th Nobel Laureate Meeting in Lindau, Germany.
- 15 April 2010
Science News
Centrosomes serve as a compass for the division of brain stem cellsResearchers at IRB Barcelona discover a mechanism responsible for the orientation of asymmetric division of neuroblasts.
- 1 March 2010
Journal of Cell Biology
Centrosomes remember which way is up - 1 February 2010
Correo Farmacéutico
Creation of Oncológica, the second biotech enterprise to receive funding from Cenit - 1 December 2009
Institute News
IRB Barcelona to participate in a CENIT consortium on cancer researchThe group headed by González joins the ONCOLOGICA project, managed by PharmaMar.
- 20 October 2009
El País
Créanselo, señores diputados - 2 October 2009
El Mundo
González: "Drosophila has marked milestones in biology" - 18 September 2009
Diario Médico
La interacción competitiva induce apoptosis en 'Drosophila' - 14 September 2009
TV3
The fly, a model for medicine - 21 April 2008
El Norte de Castilla
Un biólogo segoviano participará en una investigación científica de la Antártida
RSS
